| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S84863-1mg买3赠1 |
≥99% | ￥300.00 |
>10 | - | - | - | - |
|
S84863-2mg买3赠1 |
≥99% | ￥460.00 |
>10 | - | - | - | - |
|
S84863-5mg买3赠1 |
≥99% | ￥780.00 |
>10 | - | - | - | - |
|
S84863-10mg买3赠1 |
≥99% | ￥1400.00 |
>10 | - | - | - | - |
|
S84863-25mg买3赠1 |
≥99% | ￥2600.00 |
>10 | - | - | - | - |
|
S84863-50mg买3赠1 |
≥99% | ￥3900.00 |
10 | - | - | - | - |
|
S84863-100mg |
≥99% | ￥5930.00 |
5 | - | - | - | - |
|
| 产品描述： | GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively. | ||||||||||||||||||||
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| 靶点： | IC50: 56 nM (rat glucagon receptor), 55 nM (human glucagon receptor);GlucagonReceptor | ||||||||||||||||||||
| 体内研究： | GRA Ex-25 (3 mg/kg, i.v.) significantly reduces blood glucose caused by exogenous administration of glucagon in rat model. GRA Ex-25 is able to inhibit the rise in blood glucose levels elicited by exogenous administered glucagon, most likely because of the direct inhibition of glucagon stimulated hepatic glucose output | ||||||||||||||||||||
| 参考文献： | 1. Kurukulasuriya R, et al. Biaryl amide glucagon receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2047-50. 2. Lau J, et al. New beta-alanine derivatives are orally available glucagon receptor antagonists. J Med Chem. 2007 Jan 11;50(1):113-28. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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