Glutaminase C-IN-1

99.70%

Glutaminase C-IN-1

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品牌：源叶(MedMol)

产品编号：S84875 一键复制产品信息

CAS号：311795-38-7

分子式：C₂₇H₂₇BrN₂O

分子量：475.4201

别名：QC-219; 5-[3-bromo-4-(dimethylamino)phenyl]-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one;

货号	规格	价格	上海	北京	珠海	重庆	武汉
S84875-5mg	99.70%	￥340.00 S84875-5mg ￥340.00 现货	8 8	-	-	-	-
S84875-10mg	99.70%	￥578.00 S84875-10mg ￥578.00 现货	9 9	-	-	-	-
S84875-50mg	99.70%	￥2580.00 S84875-50mg ￥2580.00 现货	12 >10	-	-	-	-

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产品介绍参考文献(1篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts

靶点：

Glutaminase C;Glutaminase

体外研究：

Glutaminase C-IN-1 (Compound 968) (10 μM; 14 d) inhibits cellular transformation in NIH 3T3 cells. Glutaminase C-IN-1 (10 μM; 6 d) blocks the signaling activity of a specific target of Dbl. Glutaminase C-IN-1 blocks the transforming activity of human breast cancer cells. Glutaminase C-IN-1 (10 μM) blocks glutaminolysis in transformed cells. Glutaminase C-IN-1 preferentially binds to the monomeric state of Glutaminase C. Cell Viability Assay Cell Line: MDA-MB231 cells, SKBR3 cells, and NIH 3T3 cells Concentration: 10 μM Incubation Time: 5 h Result: Inhibited cell growth.

体内研究：

Glutaminase C-IN-1 (Compound 968) (200 μg/mouse; i.p.; daily for 12 days) reduces tumor volume in mice. Animal Model: SCID mice with P493 B lymphoma cells Dosage: 200 μg/mouse Administration: Intraperitoneal injection, daily for 12 days Result: Caused a ~50% reduction in the size of the tumors.

参考文献：

1. Wang JB, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2010 Sep 14;18(3):207-19. 2. Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.103 ml	10.517 ml	21.034 ml
5 mM	0.421 ml	2.103 ml	4.207 ml
10 mM	0.21 ml	1.052 ml	2.103 ml
50 mM	0.042 ml	0.21 ml	0.421 ml