| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S84911-2mg买3赠1 |
98.00% | ￥360.00 |
4 | - | - | - | - |
|
S84911-5mg买3赠1 |
98.00% | ￥560.00 |
1 | - | - | - | - |
|
S84911-10mg买3赠1 |
98.00% | ￥920.00 |
6 | - | - | - | - |
|
S84911-25mg买3赠1 |
98.00% | ￥1920.00 |
3 | - | - | - | - |
|
S84911-50mg买3赠1 |
98.00% | ￥3000.00 |
3 | - | - | - | - |
|
S84911-100mg买3赠1 |
98.00% | ￥4800.00 |
4 | - | - | - | - |
|
| 产品描述： | Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC50 of 0.278 nM | ||||||||||||||||||||
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| 靶点： | EC50: 0.278 nM (Nur77) | ||||||||||||||||||||
| 体外研究： | Cytosporone B targets the ligand binding domain of Nur77, which selectively stimulates the transactivational activity of Nur77. Cytosporone B induces luciferase activity in cells that are cotransfected with GAL4- Nur77 or GAL4-LBD. The EC50 of cytosporone B for Nur77 is 0.278 nM. Cytosporone B displays robust pro-apoptotic activity in gastric cancer cells BGC-823. 63.5% of the cells are apoptotic when treated with cytosporone B for 48 h. Cytosporone B shows selective effect on cancerous cells. Cytosporone B inhibits proliferation of human gastric cancer BGC-823 cells and human colon cancer SW620 cells by 470%, but it has a modest effect on human lung cancer H1299 cells and human hepatoma HepG2 cells | ||||||||||||||||||||
| 体内研究： | In the hepatocytes of wild-type mice, the transcriptional activity of the reporter is induced five-fold with cytosporone B treatment. In wild-type mice, cytosporone B treatment significantly increases glucose levels from 3.2 to 11.4 mM within the first 30 min, and thereafter blood glucose gradually decreased before reaching the initial level after 300 min | ||||||||||||||||||||
| 参考文献： | 1. Zhan Y, et al. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat Chem Biol. 2008 Sep;4(9):548-56. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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