| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S84969-1mg买3赠1 |
98.00% | ￥100.00 |
9 | - | - | - | - |
|
S84969-5mg买3赠1 |
98.00% | ￥129.00 |
6 | - | - | - | - |
|
S84969-10mg买3赠1 |
98.00% | ￥245.00 |
8 | - | - | - | - |
|
S84969-25mg |
98.00% | ￥510.00 |
6 | - | - | - | - |
|
S84969-50mg |
≥98% | ￥880.00 |
货期：2-3天 | - | - | - | - |
|
S84969-100mg |
≥98% | ￥1500.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Drug Metabolite;Gamma-secretase;Gamma-secretase;DrugMetabolite | ||||||||||||||||||||
| 体外研究： | IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth. A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO). | ||||||||||||||||||||
| 体内研究： | The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish. | ||||||||||||||||||||
| 参考文献： | 1. Astudillo L,et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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