货号	规格	价格	上海	北京	珠海	重庆	武汉
S84975-5mg	≥98%	￥660.00 S84975-5mg ￥660.00 3-5天	0 货期：3-5天	-	-	-	-
S84975-10mg	≥98%	￥990.00 S84975-10mg ￥990.00 3-5天	0 货期：3-5天	-	-	-	-
S84975-25mg	≥98%	￥1980.00 S84975-25mg ￥1980.00 3-5天	0 货期：3-5天	-	-	-	-
S84975-50mg	≥98%	￥3100.00 S84975-50mg ￥3100.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

C 87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.

靶点：

IC50: 8.73 μM (TNFα-induced cytotoxicity);TNF

体外研究：

C 87 (C87) directly binds to TNFα, potently inhibits TNFα-induced cytotoxicity (IC50=8.73 μM) and effectively blocks TNFα-triggered signaling activities. C 87 exhibits good solubility and consistent dose-dependent functions in vitro. C 87 completely blocks TNFα-induced activation of caspase-3 and caspase-8. The activity of c-Jun N-terminal kinase (JNK) is significantly reduced by C 87 in L929 cells. C 87 also prevents the degradation of IκBα in cells treated with TNFα. C 87 potently blocks multiple signaling transduction pathways and downstream target gene activation triggered by TNFα

体内研究：

C 87 (C87) attenuates TNFα-induced inflammation, thereby markedly reducing injuries to the liver and improving animal survival. C 87 injection delays the incidence of death and increases the survival rate by two folds compared with the vehicle control. The level of alanine transaminase and aspartate transaminase is consistently reduced in mice with C 87 treatment

参考文献：

1. Ma L, et al. A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J Biol Chem. 2014 May 2;289(18):12457-66.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.988 ml	9.942 ml	19.883 ml
5 mM	0.398 ml	1.988 ml	3.977 ml
10 mM	0.199 ml	0.994 ml	1.988 ml
50 mM	0.04 ml	0.199 ml	0.398 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

C 87

3-Phenyl-1-(4-phenyl-2-thiazolyl)-4-[(4-chloro-3-nitrophenyl)hydrazone]-1H-pyrazole-4,5-dione

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)