货号	规格	价格	上海	北京	珠海	重庆	武汉
S85043-2mg买3赠1	99.36%	￥100.00 S85043-2mg ￥100.00 现货（买3赠1）	4 4 4	2	2	-	-
S85043-5mg买3赠1	99.36%	￥140.00 S85043-5mg ￥140.00 现货（买3赠1）	4 0 4	-	-	-	-
S85043-10mg买3赠1	99.36%	￥220.00 S85043-10mg ￥220.00 现货（买3赠1）	5 2 5	2	-	-	-
S85043-50mg买3赠1	99.36%	￥780.00 S85043-50mg ￥780.00 现货（买3赠1）	4 4	-	-	-	-
S85043-100mg买3赠1	99.36%	￥1270.00 S85043-100mg ￥1270.00 现货（买3赠1）	3 3	-	-	-	-
S85043-200mg	99.36%	￥2040.00 S85043-200mg ￥2040.00 现货	4 4	-	-	-	-

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产品描述：

Alda 1是一种ALDH2激动剂，能激活野生型ALDH2 (ALDH2*1)和ALDH2*2的催化活性

靶点：

ALDH2;Apoptosis;Dehydrogenase

体外研究：

Alda-1 alleviated liver injury after hepatic I/R. Pretreatment with Alda-1 significantly alleviated I/R-induced elevations of alanine aminotransferase and aspartate aminotransferase, and significantly blunted the pathological injury of the liver. Moreover, Alda-1 significantly inhibited ROS and proinflammatory cytokines production, 4-HNE and MDA accumulation, and apoptosis. Increased ALDH2 activity was found after Alda-1 administration. No significant changes in ALDH2 expression were observed after I/R

体内研究：

Alda-1 treatment results in a significant decrease of 4-HNE-protein content in the plasma of apoE−/− mice. Alda-1 administration leads to a slight increase in gene expression related to neurogenesis (Nog), mitochondrial biogenesis (CYTB, ND1), and apoptosis (Bax, Gsk3b) in the Hp of apoE−/− mice. Alda-1 administration leads to 2 and 10 differentially expressed proteins in the FCx and Hp of apoE−/− mice, respectively.
Alda-1 (1.5 mg/kg, b.w., IP) administration significantly increases the climbing time, tends to reduce the immobility time and increases the swimming time of the prenatally stressed rats in the forced swim test. Moreover, treatment of prenatally stressed rats with Alda-1 significantly increases number of entries into the open arms of the maze and the time spent therein, as assessed by elevated plus-maze test. Alda-1 (8.5 mg/kg; IP) with glucose significantly lowers 4-HNE and FJB-positive cells in the cerebral cortex of Alda-1-treated rats than in DMSO-treated rats 24 h after glucose administration.
Alda-1 (10 mg/kg per day) treatment prevents aldehydic overload, mitochondrial dysfunction and improves ventricular function in post-MI cardiomyopathy rats.

细胞实验：

Cell lines: normal rat hepatocyte cell (BRL-3A) Concentrations: 20 μM Incubation Time: 1 hour Method: The H/R (Hypoxia/reoxygenation) group cells are incubated under a hypoxic atmosphere (95% N2+5% CO2) for 6 h followed by 120 min reoxygenation (95% air + 5% CO2). The control incubation is normoxic conditions (95% air + 5% CO2) for the entire experiment. In the H/R+Alda-1 group, cells are incubated with Alda-1 (20 μM) for 60 min at 37℃ (95% air/5% CO2) before exposure to hypoxia. Furthermore, BRL-3A cells are treated with 5 μM 4-HNE for 60min before exposure to hypoxia to estimate whether 4-HNE could affect H/R.

动物实验：

Animal Models: Male Sprague-Dawley rats (IR model) Dosages: 10 mg/kg Administration: i.p.

参考文献：

1. Samantha Perez-Miller, et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nat Struct Mol Biol. 2010, 17(2): 159-164. 2. Zhang T, et al. Alda-1, an ALDH2 activator, protects against hepatic ischemia/reperfusion injury in rats via inhibition of oxidative stress. Free Radic Res. 2018, 52(6):629-638.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.085 ml	15.424 ml	30.849 ml
5 mM	0.617 ml	3.085 ml	6.17 ml
10 mM	0.308 ml	1.542 ml	3.085 ml
50 mM	0.062 ml	0.308 ml	0.617 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

体积

分子摩尔量

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Alda-1

N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)