品牌：源叶(MedMol)

产品编号：S85073 一键复制产品信息

CAS号：35899-54-8

分子式：C₁₄H₂₁N₅O₃S

分子量：339.418

别名：5ˊ-异丁硫基-5ˊ-脱氧腺苷;5ˊ-S-(2-甲基丙基)-5ˊ-硫代腺苷;5ˊ-脱氧-5ˊ-S-异丁基硫代腺苷;5ˊ-异丁硫基-5ˊ-脱氧腺苷;5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE;5’-deoxy-5’-s-isobutylthioadenosine;5''-Deoxy-5''-S-isobutyladenosine;5μ-Deoxy-5μ-S-isobutylt;5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE

货号	规格	价格	上海	北京	珠海	重庆	武汉
S85073-5mg促销	98%	￥1010.00 ￥810.00 S85073-5mg ￥810.00 现货	10 10	-	-	-	-
S85073-25mg促销	98%	￥3700.00 ￥2960.00 S85073-25mg ￥2960.00 现货	6 6	-	-	-	-
S85073-100mg促销	98%	￥6480.00 ￥5190.00 S85073-100mg ￥5190.00 现货	2 2	-	-	-	-

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产品描述：

SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies

靶点：

Plasmodium;HSV-1;NucleosideAntimetabolite/Analog;HSV

体内研究：

SIBA (150 mg/kg; i.p.; twice weekly for 3 weeks) inhibits tumor growth in vivo. SIBA (15 mg/kg; i.p.; thrice weekly for 4 weeks) inhibits metastatic spread of RMS-J1 cells in vivo Animal Model: C57BL/6 female mice (4-8 weeks old). Dosage: 150 mg/kg Administration: Intraperitoneal injection; twice weekly for 3 weeks. Result: Significantly reduced the median number of lung metastases.

参考文献：

1. F Breillout , et al. Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines. Clin Exp Metastasis. Jan-Feb 1988;6(1):3-16. 2. B Jacquemont, et al. Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine. J Virol. 1977 Apr;22(1):160-7. 3. Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryo fibroblasts. Biochem J. 1982 Jun 15;204(3):853-9.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.946 ml	14.731 ml	29.462 ml
5 mM	0.589 ml	2.946 ml	5.892 ml
10 mM	0.295 ml	1.473 ml	2.946 ml
50 mM	0.059 ml	0.295 ml	0.589 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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