货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S85075-5mg	≥98%	￥1790.00 S85075-5mg ￥1790.00 3-5天	0 货期：3-5天	-	-	-	-
S85075-10mg	≥98%	￥2890.00 S85075-10mg ￥2890.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S85075-5mg

≥98%

￥1790.00

货期：3-5天

S85075-10mg

≥98%

￥2890.00

货期：3-5天

产品描述：

RNPA1000, an antibiotic, is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity

靶点：

Antibiotic;Bacterial

体外研究：

RNPA1000 displays antimicrobial activity toward Gram-positive bacteria and little or no toxicity toward human cells. RNPA1000 limits S. aureus mRNA turnover and growth. RNPA1000 also limits growth of other important Gram-positive bacterial pathogens, exhibits antimicrobial efficacy against biofilm associated S. aureus and protects against the S. aureus pathogenesis in an animal model of infection. RNPA1000 (IC50= 100-125 µM), does not affect the activity of the commercially available E. coli RNase HI, RNase A, RNase I or in-house purified S. aureus RNase J1 at any concentration tested (0-750 µM), but does mildly inhibit E. coli RNase III activity (IC50= 500-750 µM)

参考文献：

1. Eidem TM, et al. Drug-eluting cements for hard tissue repair: a comparative study using vancomycin and RNPA1000 to inhibit growth of Staphylococcus aureus. J Biomater Appl. 2014 Apr;28(8):1235-46. 2. Eidem TM, et al. Small-molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing. Antimicrob Agents Chemother. 2015 Apr;59(4):2016-28. 3. Patrick D Olson, et al. Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis. PLoS Pathog. 2011 Feb 10;7(2):e1001287.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.154 ml	10.769 ml	21.537 ml
5 mM	0.431 ml	2.154 ml	4.307 ml
10 mM	0.215 ml	1.077 ml	2.154 ml
50 mM	0.043 ml	0.215 ml	0.431 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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