货号	规格	价格	上海	北京	珠海	重庆	武汉
S85092-2mg买3赠1	99.50%	￥312.00 S85092-2mg ￥312.00 现货（买3赠1）	4 4	-	-	-	-
S85092-5mg买3赠1	99.50%	￥430.00 S85092-5mg ￥430.00 现货（买3赠1）	6 6	-	-	-	-
S85092-10mg买3赠1	99.50%	￥720.00 S85092-10mg ￥720.00 现货（买3赠1）	6 6	-	-	-	-
S85092-50mg买3赠1	99.50%	￥2340.00 S85092-50mg ￥2340.00 现货（买3赠1）	2 2	-	-	-	-
S85092-100mg	≥99%	￥3510.00 S85092-100mg ￥3510.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

(±)-Ibipinabant ((±)-SLV319) is the racemate of SLV319. (±)-Ibipinabant ((±)-SLV319) is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC50 of 22 nM.

靶点：

IC50: 22 nM (CB-1); Ki: 7.8 nM (CB-1);CannabinoidReceptor

体内研究：

(±)-Ibipinabant ((±)-SLV319) (3 mg/kg) reduces unfasted glucose to a significantly greater degree than rimonabant at the same dose on days 17, 28 and 38. Chronic treatment with (±)-Ibipinabant ((±)-SLV319) significantly attenuates the progression of diabetes in ZDF rats, blunting the increase in blood glucose and HbA1c over time. Ibipinabant also reduces the hyperinsulinemia apparent at 6-8 weeks of age and attenuates the dramatic reduction in insulin levels observed 1-2 weeks later

参考文献：

1. Chorvat RJ, et al. JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6173-80. 2. Lange JH, et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. J Med Chem. 2004 Jan 29;47(3):627-43. 3. Rohrbach K, et al. Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its effects on body weight. Diabetes Obes Metab. 2012 Jun;14(6):555-64.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.052 ml	10.258 ml	20.517 ml
5 mM	0.41 ml	2.052 ml	4.103 ml
10 mM	0.205 ml	1.026 ml	2.052 ml
50 mM	0.041 ml	0.205 ml	0.41 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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