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SLV-319

    
99.50%

SLV-319

源叶(MedMol)
S85092 一键复制产品信息
362519-49-1
C23H20Cl2N4O2S
487.409
(±)-Ibipinabant
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S85092-2mg买3赠1
99.50%

¥312.00

4 - - - -
S85092-5mg买3赠1
99.50%

¥430.00

6 - - - -
S85092-10mg买3赠1
99.50%

¥720.00

6 - - - -
S85092-50mg买3赠1
99.50%

¥2340.00

2 - - - -
S85092-100mg
≥99%

¥3510.00

货期:2-3天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: (±)-Ibipinabant ((±)-SLV319) is the racemate of SLV319. (±)-Ibipinabant ((±)-SLV319) is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC50 of 22 nM.
靶点: IC50: 22 nM (CB-1); Ki: 7.8 nM (CB-1);CannabinoidReceptor
体内研究: (±)-Ibipinabant ((±)-SLV319) (3 mg/kg) reduces unfasted glucose to a significantly greater degree than rimonabant at the same dose on days 17, 28 and 38. Chronic treatment with (±)-Ibipinabant ((±)-SLV319) significantly attenuates the progression of diabetes in ZDF rats, blunting the increase in blood glucose and HbA1c over time. Ibipinabant also reduces the hyperinsulinemia apparent at 6-8 weeks of age and attenuates the dramatic reduction in insulin levels observed 1-2 weeks later
参考文献: 1. Chorvat RJ, et al. JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6173-80. 2. Lange JH, et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. J Med Chem. 2004 Jan 29;47(3):627-43. 3. Rohrbach K, et al. Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its effects on body weight. Diabetes Obes Metab. 2012 Jun;14(6):555-64.
溶解性: Soluble  in  DMSO
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.052 ml 10.258 ml 20.517 ml
5 mM 0.41 ml 2.052 ml 4.103 ml
10 mM 0.205 ml 1.026 ml 2.052 ml
50 mM 0.041 ml 0.205 ml 0.41 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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