货号	规格	价格	上海	北京	珠海	重庆	武汉
S85097-25mg买3赠1	99.20%	￥140.00 S85097-25mg ￥140.00 现货（买3赠1）	8 8	-	-	-	-
S85097-100mg买3赠1	99.20%	￥320.00 S85097-100mg ￥320.00 现货（买3赠1）	7 7	-	-	-	-
S85097-500mg买3赠1	99.20%	￥1420.00 S85097-500mg ￥1420.00 现货（买3赠1）	7 7	-	-	-	-
S85097-1g买3赠1	99.20%	￥2650.00 S85097-1g ￥2650.00 现货（买3赠1）	6 6	-	-	-	-

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产品描述：

Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.

靶点：

Sigma Receptor;Sigmareceptor

体内研究：

Dimemorfan (6.25 or 12.5 mg/kg, s.c.) significantly attenuates the BAY k-8644-induced convulsive behaviors, in a dose-related manner (6.25 mg/kg dimemorfan+BAY k-8644 or 12.5 mg/kg dimemorfan+BAY k-8644 versus Saline+BAY k-8644, P<0.05 and P<0.01, respectively). Dimemorfan significantly attenuates BAY k-8644-induced increases in the c-fos and c-jun protein expression in a dose-dependent manner. Dimemorfan does not significantly affect locomotor activity or produce significant circling behavior in any locomotor pattern in mice. Dimemorfan (1 and 5 mg/kg, i.p.) surpresses the incarease of the plasma levels of TNF-α in mice. The infiltration of neutrophils into lung and liver as well as the production of oxidative stress (EB staining) in these tissues induced by LPS is markedly inhibited by the treatment with dimemorfan

参考文献：

1. Shin EJ, et al. Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice. Behav Brain Res. 2004 May 5;151(1-2):267-76. 2. Wang YH, et al. Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice. Br J Pharmacol. 2008 Jul;154(6):1327-38.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.83 ml	14.148 ml	28.297 ml
5 mM	0.566 ml	2.83 ml	5.659 ml
10 mM	0.283 ml	1.415 ml	2.83 ml
50 mM	0.057 ml	0.283 ml	0.566 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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