货号	规格	价格	上海	北京	珠海	重庆	武汉
S85114-5mg买3赠1	99.90%	￥180.00 S85114-5mg ￥180.00 现货（买3赠1）	1697 >10	-	-	-	-
S85114-10mg买3赠1	99.90%	￥300.00 S85114-10mg ￥300.00 现货（买3赠1）	854 >10	-	-	-	-
S85114-50mg买3赠1	99.90%	￥748.00 S85114-50mg ￥748.00 现货（买3赠1）	178 >10	-	-	-	-
S85114-100mg买3赠1	99.90%	￥1080.00 S85114-100mg ￥1080.00 现货（买3赠1）	94 >10	-	-	-	-

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产品描述：

Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

靶点：

5-HT7 Receptor：0.495 nM (IC50)；5-HT1A Receptor：6.75 nM (IC50)；D2 Receptor：1.68 nM (IC50);DopamineReceptor;5-HTReceptor;Norepinephrine

体内研究：

Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) dose-dependently increases the ratio of DOPAC/dopamine in both regions, but it shows a preferential effect on the frontal cortex compare with the striatum, especially at higher doses. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) (ED50 values 2.3 to 5.0 mg/kg) shows a comparable potency with olanzapine (ED50 values 1.1 to 5.1 mg/kg), higher potency than clozapine (ED50 9.5 to 290 mg/kg), and slightly lower potency than haloperidol (ED50 values 0.44 to 1.7 mg/kg). Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) (1 to 10 mg/kg) dose-dependently inhibits conditioned avoidance response (CAR) in rats, and the ED50 values are 6.3 mg/kg. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) dose-dependently inhibits TRY-induced forepaw clonic seizure and p-CAMP-induced hyperthermia with ED50 values of 5.6 and 3.0 mg/kg, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) (0.3 to 30 mg/kg) dose-dependently and significantly increases the number of shocks received by rats in the conflict test with MED of 10 mg/kg (p<0.01)

参考文献：

1. Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334(1):171-81. 2. Sakine Atila Karaca, et al. Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals. Marmara Pharm J. 2017;21 (4): 931-937.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.89 ml	9.449 ml	18.899 ml
5 mM	0.378 ml	1.89 ml	3.78 ml
10 mM	0.189 ml	0.945 ml	1.89 ml
50 mM	0.038 ml	0.189 ml	0.378 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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Lurasidone Hydrochloride