货号	规格	价格	上海	北京	珠海	重庆	武汉
S85122-10mg买3赠1	99.80%	￥80.00 S85122-10mg ￥80.00 现货（买3赠1）	6 6	-	-	-	-
S85122-50mg买3赠1	99.80%	￥200.00 S85122-50mg ￥200.00 现货（买3赠1）	2 2	-	-	-	-
S85122-250mg	99.80%	￥300.00 S85122-250mg ￥300.00 现货	1 1	-	-	-	-
S85122-1g	≥98%	￥880.00 S85122-1g ￥880.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Zebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor. Zebularine also inhibits cytidine deaminase with a Ki of 0.95 μM.

靶点：

DNMT1;DNMT3a/3L;Cytidine deaminase:0.95 μM (Ki);Autophagy ;DNAMethyltransferase;Autophagy

体内研究：

Zebularine is only slightly cytotoxic to tumor-bearing mice. Compared with those in control mice, tumor volumes are statistically significantly reduced in mice treated with high-dose zebularine administered by intraperitoneal injection or by oral gavage. Zebularine also enhances the survival time of mice with L1210 leukemia treated with 5-AZA-CdR. About 27% of the mice treated with this drug combination has a survival time longer than the mice treated with only 5-AZA-CdR

参考文献：

1. Champion C, et al. Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine. PLoS One. 2010 Aug 24;5(8):e12388. 2. Cheng JC, et al. Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst. 2003 Mar 5;95(5):399-409. 3. Billam M, et al. Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells. Breast Cancer Res Treat. 2010 Apr;120(3):581-92. 4. Lemaire M, et al. Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine. Cancer Chemother Pharmacol. 2009 Feb;63(3):411-6.

溶解性：

Soluble in DMSO、H2O

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.382 ml	21.911 ml	43.821 ml
5 mM	0.876 ml	4.382 ml	8.764 ml
10 mM	0.438 ml	2.191 ml	4.382 ml
50 mM	0.088 ml	0.438 ml	0.876 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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2-Pyrimidone-1-Beta-D-Riboside