| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85123-5mg买3赠1 |
97.00% | ￥238.00 |
6 | - | - | - | - |
|
S85123-10mg买3赠1 |
97.00% | ￥269.00 |
5 | - | - | - | - |
|
S85123-25mg买3赠1 |
97.00% | ￥590.00 |
5 | - | - | - | - |
|
S85123-50mg买3赠1 |
97.00% | ￥940.00 |
5 | - | - | - | - |
|
S85123-100mg买3赠1 |
97.00% | ￥1510.00 |
4 | - | - | - | - |
|
S85123-200mg买3赠1 |
≥96% | ￥2800.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM). Icilin is a “super-cooling agent”. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | TRPM8;TRP/TRPVChannel | ||||||||||||||||||||
| 体内研究： | Icilin is a transient receptor potential cation channel subfamily M (TRPM8) agonist that produces behavioral activation in rats and mice. Icilin (3 mg/kg; s.c.) induces“Wet dog shake” in mice | ||||||||||||||||||||
| 参考文献： | 1. Huai-hu Chuang, et al. The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron. 2004 Sep 16;43(6):859-69. 2. Viktor V Feketa,et al. Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. Crit Care Med. 2014 May;42(5):e355-63. 3. Benjamin W Ewanchuk, et al. The cooling compound icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response. FASEB J. 2018 Mar;32(3):1236-1249. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | RT | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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