| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85138-2mg买3赠1 |
99.90% | ￥180.00 |
9 | - | - | - | - |
|
S85138-5mg买3赠1 |
99.90% | ￥290.00 |
9 | - | - | - | - |
|
S85138-10mg买3赠1 |
99.90% | ￥340.00 |
5 | - | - | - | - |
|
S85138-25mg买3赠1 |
99.90% | ￥460.00 |
6 | - | - | - | - |
|
S85138-50mg买3赠1 |
99.90% | ￥690.00 |
4 | - | - | - | - |
|
S85138-100mg |
99.90% | ￥830.00 |
3 | - | - | - | - |
|
| 产品描述： | TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1 | ||||||||||||||||||||
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| 靶点： | OX2 Receptor;OXReceptor | ||||||||||||||||||||
| 体外研究： | TCS-OX2-29 inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor | ||||||||||||||||||||
| 体内研究： | TCS-OX2-29 (5-10 mg/kg; intraperitoneal injection; adult male NMRI mice) treatment suppresses conditioned place preference (CPP) acquisition and expression in both naïve and dependent mice significantly. Animal Model: 440 adult male NMRI mice (25-30 g) Dosage: 5 mg/kg and 10 mg/kg Administration: Intraperitoneal injection (Pharmacokinetic study) Result: Suppressed conditioned place preference (CPP) acquisition and expression in both naïve and dependent mice significantly. | ||||||||||||||||||||
| 参考文献： | 1. Hirose M et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidicantagonist. Bioorg Med Chem Lett, 2003 Dec 15, 13(24):4497-9. 2. R Mould et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol. 2014 Jan; 171(2): 351-363. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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