货号	规格	价格	上海	北京	珠海	重庆	武汉
S85167-1mg买3赠1	99.80%	￥196.00 S85167-1mg ￥196.00 现货（买3赠1）	6 6	-	-	-	-
S85167-2mg买3赠1	99.80%	￥340.00 S85167-2mg ￥340.00 现货（买3赠1）	7 7	-	-	-	-
S85167-5mg买3赠1	99.80%	￥646.00 S85167-5mg ￥646.00 现货（买3赠1）	6 6	-	-	-	-
S85167-25mg促销	99.80%	￥910.00 ￥728.00 S85167-25mg ￥728.00 现货	5 5	-	-	-	-
S85167-10mg买3赠1	99.80%	￥820.00 S85167-10mg ￥820.00 现货（买3赠1）	6 6	-	-	-	-
S85167-50mg促销	≥98%	￥1560.00 ￥1240.00 S85167-50mg ￥1240.00 2-3天	0 货期：2-3天	-	-	-	-
S85167-100mg促销	≥98%	￥2850.00 ￥2280.00 S85167-100mg ￥2280.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 52 nM.

靶点：

IC50: 52 nM (11β-HSD1);Dehydrogenase

体外研究：

Selective inhibition of 11β-HSD1 decreases blood glucose concentrations in hyperglycaemic mice. Selective inhibitors of 11β-HSD1 have considerable potential as treatments for a number of diseases of great unmet medical need such as type 2 diabetes, obesity and metabolic syndrome, a multifactorial disorder. BVT-14225 shows high activity in the enzyme assay with 90% inhibition at 10 μM. It has an IC50 for 11β-HSD1 on a human enzyme assay of 52 nM

参考文献：

1. Barf T, et al. Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2002 Aug 29;45(18):3813-5. 2. Vicker N, et al. Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol. 2007 May;104(3-5):123-9.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.488 ml	12.44 ml	24.88 ml
5 mM	0.498 ml	2.488 ml	4.976 ml
10 mM	0.249 ml	1.244 ml	2.488 ml
50 mM	0.05 ml	0.249 ml	0.498 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置