| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85168-2mg买3赠1 |
95.40% | ￥160.00 |
5 | - | - | - | - |
|
S85168-5mg买3赠1 |
95.40% | ￥300.00 |
6 | - | - | - | - |
|
S85168-10mg买3赠1 |
95.40% | ￥500.00 |
6 | - | - | - | - |
|
S85168-25mg促销 |
95.40% | ￥1000.00 ￥800.00 |
6 | - | - | - | - |
|
S85168-50mg促销 |
95.40% | ￥1650.00 ￥1320.00 |
4 | - | - | - | - |
|
S85168-100mg促销 |
≥95% | ￥2400.00 ￥1920.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | BVT 2733 is a potent, selective, and orally active non-steroidal 11β-hydroxydehydrogenase 1 (11β-HSD1) inhibitor. BVT 2733 is potently against the mouse enzyme (IC50=96 nM) over the human enzyme (IC50=3341 nM). BVT 2733 has the potential for the study of arthritis and obesity related disease | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 96 nM (mouse 11β-HSD1) IC50: 3341 nM (human 11β-HSD1);Dehydrogenase | ||||||||||||||||||||
| 体外研究： | BVT 2733 (100 μM; 24 hours) co-treatment with PA (100 µM) reduces MCP-1 expression in fully differentiation adipocytes. BVT 2733 (50-100 μM; 24 hours) reduces the inflammation protein levels (MCP-1, IL-6) in medium in J774.1 macrophages by Elisa. RT-PCR Cell Line: Differentiation adipocytes Concentration: 100 μM Incubation Time: 24 hours Result: Down-regulated MCP-1 mRNA level. | ||||||||||||||||||||
| 体内研究： | BVT-2733 (oral administration; 100 mg/kg; twice daily; 2 weeks) attenuates the arthritis severity and anti-CII level and decreases the levels of serum TNF-α, IL-1β, IL-6 and IL-17 in CIA mice. BVT 2733 (oral administration; 100 mg/kg; dosed (09.00 and 17.00 h); last 4 weeks) exhibits decreased body weight and enhanced glucose tolerance and insulin sensitivity when it compares to control mice. It also down-regulated the expression of inflammation-related genes including monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α) and the number of infiltrated macrophages within the adipose tissue in vivo. Animal Model: Collagen-induced arthritis (CIA) mice Dosage: 100 mg/kg Administration: Oral administration; twice daily; 2 weeks Result: Reduced synovial inflammation and joint destruction. Animal Model: C57BL/6J mice Dosage: 100 mg/kg Administration: Oral administration; dosed (09.00 and 17.00 h); last 4 weeks Result: Improved metabolic homeostasis and suppressed the inflammation of adipose tissue in diet-induced obese mice. | ||||||||||||||||||||
| 参考文献： | 1. 11β-hydroxydehydrogenase 1 (11β-HSD1) Inhibitor in Development 2. Zhang L, et al. 11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov;17(3):489-94. 3. Wang L, et al. BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. PLoS One. 2012;7(7):e40056. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京