CLOFOCTOL

99.40%

CLOFOCTOL

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品牌：源叶(MedMol)

产品编号：S85170 一键复制产品信息

CAS号：37693-01-9

分子式：C₂₁H₂₆Cl₂O

分子量：365.34

别名：叔辛酚氯;氯福克酚;CLOFOCTOL;2-[2,4-DICHLOROBENZYL]-4-[1,1,3,3-TETRAMETHYLBUTYL]PHENOL;2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethylbutyl)-pheno;2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethylbut

货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S85170-100mg	99.40%	￥670.00 S85170-100mg ￥670.00 现货	5 5	-	-	-	-
S85170-250mg	≥99%	￥1450.00 S85170-250mg ￥1450.00 2-3天	0 货期：2-3天	-	-	-	-

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产品介绍参考文献(1篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency

靶点：

Bacterial;SARS-CoV;Antibiotic;Antibacterial;Antibiotic

体内研究：

Clofoctol (175 mg/kg; i.p.; daily for 37 days) is capable of blocking tumour growth without apparent toxicity in a mouse model of human prostate cancer xenograft. Clofoctol (62.5 mg/kg; i.p.; twice) inhibits SARS-CoV-2 replication and lowers inflammation in lungs in mice with SARS-CoV-2 infection Animal Model: Male athymic nude mice (BALB/c, nu/nu-NCr) aged 4–6 weeks, human prostate cancer xenograft model Dosage: 175 mg/kg Administration: Intraperitoneal injection, daily for 37 days Result: Significantly inhibited PC3 tumour growth, tumour weight was also reduced by 60%.

参考文献：

1. Ghilardi PL, et al. Treatment of ear, nose and throat infections with clofoctol. Drugs Exp Clin Res. 1985;11(11):815-8. 2. Wang M, et al. Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer. Br J Pharmacol. 2014 Oct;171(19):4478-89. 3. Belouzard S, et al. Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice. PLoS Pathog. 2022 May 19;18(5):e1010498.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.737 ml	13.686 ml	27.372 ml
5 mM	0.547 ml	2.737 ml	5.474 ml
10 mM	0.274 ml	1.369 ml	2.737 ml
50 mM	0.055 ml	0.274 ml	0.547 ml