货号	规格	价格	上海	北京	珠海	重庆	武汉
S85281-2mg买3赠1	98.30%	￥300.00 S85281-2mg ￥300.00 现货（买3赠1）	5 5	-	-	-	-
S85281-5mg	98.30%	￥450.00 S85281-5mg ￥450.00 现货	5 5	-	-	-	-
S85281-10mg	98.30%	￥720.00 S85281-10mg ￥720.00 现货	4 4	-	-	-	-

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产品描述：

ONO-AE3-208 is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer

靶点：

FP:790 nM (Ki);TP Receptor:2400 nM (Ki);EP4:1.3 nM (Ki);EP3:30 nM (Ki);ProstaglandinReceptor

体内研究：

ONO-AE3-208 surpresses the in vivo bone metastasis of PC3 cells in mice. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls

参考文献：

1. Kenji Kabashima, et al. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest. 2002 Apr;109(7):883-93. 2. Ren Y, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62(6):1123-8. 3. Xu S, et al. An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer. Cell Biochem Biophys. 2014 Apr 18. 4. Xu S, et al. Inhibitory effect of ONO-AE3-208 on the formation of bone metastasis of prostate cancer in mice. Zhonghua Nan Ke Xue. 2014 Aug;20(8):684-9. 5. Thieme K, et al. EP4 inhibition attenuates the development of diabetic and non-diabetic experimental kidney disease. Sci Rep. 2017 Jun 13;7(1):3442.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.473 ml	12.363 ml	24.726 ml
5 mM	0.495 ml	2.473 ml	4.945 ml
10 mM	0.247 ml	1.236 ml	2.473 ml
50 mM	0.049 ml	0.247 ml	0.495 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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