货号	规格	价格	上海	北京	珠海	重庆	武汉
S85296-5mg	≥98%	￥140.00 S85296-5mg ￥140.00 现货	5 5	-	-	-	-
S85296-10mg	≥98%	￥210.00 S85296-10mg ￥210.00 现货	7 7	-	-	-	-
S85296-25mg	≥98%	￥330.00 S85296-25mg ￥330.00 现货	6 6	-	-	-	-
S85296-100mg	≥98%	￥590.00 S85296-100mg ￥590.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic and antiallodynic properties

靶点：

Cannabinoid Receptor;CannabinoidReceptor

体外研究：

analgesic, antihyperalgesic, and antiallodynic properties in rat models of acute and chronic pain. The reference concentration is 10 μM

体内研究：

In rat models of chronic neuropathic (chronic constriction injury, spared nerve injury, tibial nerve injury, and spinal nerve ligation models) and inflammatory pain (carrageenan and complete Freund's adjuvant models), BAY 59-3074 (0.3-3 mg/kg, p.o.) induced antihyperalgesic and antiallodynic effects against thermal or mechanical stimuli. Antiallodynic efficacy of BAY 59-3074 (1 mg/kg, p.o.) in the spared nerve injury model was maintained after 2 weeks of daily administration. However, tolerance developed rapidly (within 5 days) for cannabinoid-related side effects, which occur at doses above 1 mg/kg (e.g., hypothermia). Uptitration from 1 to 32 mg/kg p.o. (doubling of daily dose every 4th day) prevented the occurrence of such side effects, whereas antihyperalgesic and antiallodynic efficacy was maintained/increased. No withdrawal symptoms were seen after abrupt withdrawal following 14 daily applications of 1 to 10 mg/kg p.o.

参考文献：

1. De Vry J, et al. 3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): a novel cannabinoid Cb1/Cb2 receptor partial agonist with antihyperalgesic and antiallodynic effects. J Pharmacol Exp Ther. 2004 Aug;310(2):620-32. 2. De Vry J, et al. Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat. Eur J Pharmacol. 2004 Nov 28;505(1-3):127-33.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.206 ml	11.029 ml	22.058 ml
5 mM	0.441 ml	2.206 ml	4.412 ml
10 mM	0.221 ml	1.103 ml	2.206 ml
50 mM	0.044 ml	0.221 ml	0.441 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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