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CASIN

    
99.80%

CASIN

源叶(MedMol)
S85347 一键复制产品信息
425399-05-9
C20H22N2O
306.4
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S85347-5mg买3赠1
99.80%

¥130.00

6 - - - -
S85347-10mg
99.80%

¥210.00

9 - - - -
S85347-25mg
99.80%

¥460.00

6 - - - -
S85347-100mg
≥98%

¥1200.00

货期:2-3天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: CASIN (Pirl1-related Compound 2) 可直接抑制 Cdc42/RhoGDI 的激活,其IC50值为2 μM
靶点: Cdc42/RhoGDI(Cell-free assay):2 μM;CDK;STAT;Ras
体外研究: CASIN facilitates the eradication of ALL LSCs by AraC + QC and prolongs the survival of both primary and secondary recipients without affecting long-term normal human hematopoiesis
体内研究: The combination of CASIN with the AraC + QC regimen eliminates quiescent LSCs and prolongs the survival of xenografted mice
细胞实验: Cell lines: Human ALL cell line Molt4-Luc2 expressing luciferase maker Concentrations: 5 μM Incubation Time: -- Method: For in vitro studies, CASIN (containing 0.02-0.2% DMSO) was used at 5 μM in the culture medium.
动物实验: Animal Models: Humanized NSGS mice expressing transgenic cDNA encoding human SCF, GM-SCF, and IL-3 (NOD SCID IL-2Rγ -/- SCF, GM-CSF, and IL-3) 36 Dosages: 2.4 mg/kg Administration: i.p.
参考文献: 1. Jeffrey R Peterson, et al. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. nChem Biol. 2006 Apr;13(4):443-52. 2. Wu L, et al. Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia. Nat Commun. 2021 Nov 26;12(1):6936.
溶解性: Soluble  in  DMSO、Ethanol
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.264 ml 16.319 ml 32.637 ml
5 mM 0.653 ml 3.264 ml 6.527 ml
10 mM 0.326 ml 1.632 ml 3.264 ml
50 mM 0.065 ml 0.326 ml 0.653 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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