货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S85361-5mg	≥98%	￥2890.00 S85361-5mg ￥2890.00 3-5天	0 货期：3-5天	-	-	-	-
S85361-10mg	≥98%	￥4190.00 S85361-10mg ￥4190.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting an EC50 for HQ-415 is 15 μM.

体外研究：

HQ-415 is active in the TDP-43 model, but CQ was not HQ-161 and HQ-415 is retested in the dose for their ability to rescue TDP-43. HQ-415 strongly synergizes with CQ at multiple concentrations in cells expressing α-syn. CQ fails to synergize with HQ-161 and actually antagonizes HQ-161 rescuing activity, in TDP-43-expressing cells. In contrast, despite the fact that CQ was completely inactive against TDP-43, it strongly synergized with HQ-415, decreasing the EC50 from 16 to 5 μM. Both HQ-161 and HQ-415 rescue TDP-43 toxicity. In cells expressing α-syn, HQ-161, despite being inactive on its own, synergized with HQ-415, reducing the EC50 from 21 to 14 μM.

参考文献：

1. Tardiff DF, et al. Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms. J Biol Chem. 2012 Feb 3;287(6):4107-4120.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.407 ml	12.034 ml	24.068 ml
5 mM	0.481 ml	2.407 ml	4.814 ml
10 mM	0.241 ml	1.203 ml	2.407 ml
50 mM	0.048 ml	0.241 ml	0.481 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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