货号	规格	价格	上海	北京	珠海	重庆	武汉
S85366-5mg买3赠1	99.20%	￥440.00 S85366-5mg ￥440.00 现货（买3赠1）	5 5	-	-	-	-
S85366-10mg买3赠1	99.20%	￥800.00 S85366-10mg ￥800.00 现货（买3赠1）	6 6	-	-	-	-
S85366-25mg买3赠1	99.20%	￥1500.00 S85366-25mg ￥1500.00 现货（买3赠1）	6 6	-	-	-	-
S85366-50mg买3赠1	≥97%	￥2800.00 S85366-50mg ￥2800.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S85366-100mg买3赠1	≥97%	￥4800.00 S85366-100mg ￥4800.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell.

靶点：

Histone Methyltransferase;HistoneMethyltransferase

体外研究：

BCI-121 significantly reduced the proliferation of HT29 (by 46%) and HCT116 (by 54%) cells at 72 h and decreased the expression levels of SMYD3 target genes. BCI-121 treatment only affected proliferation of cancer cell lines expressing high levels of SMYD3. The high levels of SMYD3 expression detected in OVCAR-3 cells, along with the strong reduction in proliferation rate observed upon BCI-121 treatment.

细胞实验：

Cell proliferation is determined using the cell proliferation reagent WST-1. Cells are seeded into 96-well plates one day before treatment. After 48 h, 72 h, or 96 h of BCI-121 or DMSO exposure, 10 μL of the Cell Proliferation Reagent WST-1 are added to each well and incubated at 37 °C in a humidified incubator for up to 1 h. Absorbance is measured on a microplate reader at 450/655 nm. The proliferation index is calculated as the ratio of WST-1 absorbance of treated cells to WST-1 absorbance of control cells.

参考文献：

1. Peserico A, et al. A SMYD3 Small-Molecule Inhibitor Impairing Cancer Cell Growth. J Cell Physiol. 2015 Oct;230(10):2447-2460.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.939 ml	14.697 ml	29.393 ml
5 mM	0.588 ml	2.939 ml	5.879 ml
10 mM	0.294 ml	1.47 ml	2.939 ml
50 mM	0.059 ml	0.294 ml	0.588 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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