货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S85401-5mg	98.01%	￥220.00 S85401-5mg ￥220.00 现货	6 6	-	-	-	-
S85401-10mg	98.01%	￥350.00 S85401-10mg ￥350.00 现货	4 4	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S85401-5mg

98.01%

￥220.00

S85401-10mg

98.01%

￥350.00

产品描述：

CDDO-Im (RTA-403) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ

靶点：

PPARα:232 nM (Ki);PPARγ:344 nM (Ki);Nrf2;Ferroptosis;Nrf2;PPAR

体外研究：

CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines (IC50 approximately 10-30 nM). In U937 leukemia cells, CDDO-Im also induces monocytic differentiation as measured by increased cell surface expression of CD11b and CD36. Treatment with CDDO-Im elevates protein levels of Nrf2, a transcription factor previously shown to bind ARE sequences, and increases expression of a number of antioxidant and detoxification genes regulated by Nrf2. CDDO-Im is one of the most potent synthetic triterpenoids shown to induce growth inhibition and apoptosis in various human cancer cells, including multiple myeloma, lung, pancreas and breast cancer. CDDO-Im treatment markedly induces cell cycle arrest at G2/M-phase and apoptosis in the triple-negative breast cancer cell lines, SUM159 and MDA-MB-231. The CD24−/EpCAM+ cells in SUM159 tumorspheres are significantly inhibited by CDDO-Im treatment. CDDO-Im also significantly decreases sphere forming efficiency and tumorsphere size in both primary and secondary sphere cultures.

体内研究：

CDDO-Im is a potent inhibitor of de novo inducible nitric oxide synthase expression in primary mouse macrophages. Moreover, CDDO-Im inhibits growth of B16 murine melanoma and L1210 murine leukemia cells in vivo. Injection of 10 nM (5.4 μg) of CDDO-Im almost completely blocks the ability of IFN-γ to induce iNOS, and treatment with as little as 1 nmol of CDDO-Im (0.54 μg) is partially effective.

参考文献：

1. Place AE, et al. The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clin Cancer Res. 2003 Jul;9(7):2798-806. 2. Liby K, et al. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Res. 2005 Jun 1;65(11):4789-98. 3. So JY, et al. A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer. PLoS One. 2014 Sep 17;9(9):e107616.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.846 ml	9.23 ml	18.46 ml
5 mM	0.369 ml	1.846 ml	3.692 ml
10 mM	0.185 ml	0.923 ml	1.846 ml
50 mM	0.037 ml	0.185 ml	0.369 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(2篇)

2. [IF=5.778] Yongming Wu et al."Acute exposure to environmentally relevant concentrations of Chinese PFOS alternative F-53B induces oxidative stress in early developing zebrafish."Chemosphere. 2019 Nov;235:945 1. Yongming Wu, Jing Huang, Mi Deng, Yuanxiang Jin, Huilin Yang, Yu Liu, Qinyan Cao, Jan A. Mennigen, Wenqing Tu, Acute exposure to environmentally relevant concentrations of Chinese PFOS alternative F-53B induces oxidative stress in early developing zebrafis

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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分子摩尔量

计算重置

CDDO Imidazolide