货号	规格	价格	上海	北京	珠海	重庆	武汉
S85416-1mg	≥99%	￥110.00 S85416-1mg ￥110.00 现货	9 9	-	-	-	-
S85416-2mg	≥99%	￥160.00 S85416-2mg ￥160.00 现货	10 10	-	-	-	-
S85416-5mg	≥99%	￥210.00 S85416-5mg ￥210.00 现货	9 9	-	-	-	-
S85416-10mg	≥99%	￥320.00 S85416-10mg ￥320.00 现货	10 10	-	-	-	-
S85416-25mg	≥99%	￥510.00 S85416-25mg ￥510.00 现货	9 9	-	-	-	-
S85416-50mg	≥99%	￥760.00 S85416-50mg ￥760.00 现货	4 4	-	-	-	-
S85416-100mg	≥99%	￥1140.00 S85416-100mg ￥1140.00 现货	4 4	-	-	-	-

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产品描述：

SB756050 is a selective TGR5 agonist. SB756050 has the potential for type 2 diabetes treatment.

靶点：

G protein-coupled Bile Acid Receptor 1;GPCR19

体外研究：

TGR5 is a bile acid receptor and a potential target for the treatment of type 2 diabetes (T2D)

体内研究：

SB756050 is well‐tolerated; it is readily absorbed, exhibited nonlinear pharmacokinetics with a less than dose‐proportional increase in plasma exposure above 100 mg, and demonstrates no significant changes in exposure when co‐administered with sitagliptin. SB756050 demonstrates highly variable pharmacodynamic effects both within dose groups and between doses, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different

参考文献：

1. Hodge RJ, et al. Safety, Pharmacokinetics, and Pharmacodynamic Effects of a Selective TGR5 Agonist, SB-756050, in Type 2 Diabetes. Clin Pharmacol Drug Dev. 2013 Jul;2(3):213-22.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.998 ml	9.988 ml	19.977 ml
5 mM	0.4 ml	1.998 ml	3.995 ml
10 mM	0.2 ml	0.999 ml	1.998 ml
50 mM	0.04 ml	0.2 ml	0.4 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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