| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85422-1mg买3赠1 |
≥98% | ￥190.00 |
货期：2-3天 | - | - | - | - |
|
S85422-5mg买3赠1 |
99.90% | ￥476.00 |
1 | - | - | - | - |
|
S85422-10mg买3赠1 |
99.90% | ￥714.00 |
6 | - | - | - | - |
|
S85422-50mg买3赠1 |
99.90% | ￥2700.00 |
8 | - | - | - | - |
|
S85422-100mg买3赠1 |
99.90% | ￥3900.00 |
4 | - | - | - | - |
|
| 产品描述： | Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | ERK1;ERK2;PiezoChannel | ||||||||||||||||||||
| 体外研究： | Yoda1 (0-6 μM, 5 min) induces the activation of both Akt and ERK1/2, which is not dependent on Piezo1. Yoda1 (1.5 μM, 5 min) inhibits Rac1 activation. Western Blot Analysis Cell Line: human coronary artery endothelial cells (HCAECs)[2], A431 cells Concentration: 0, 1.5, 3.0, and 6.0 μM Incubation Time: 5 min Result: Induced the activation of both Akt and ERK1/2, and increased the phosphorylation levels of both Akt and ERK1/2 in a dose-dependent manner. Inhibited EGF-induced increase in the amount of Rac1-GTP, and inhibited Rac1 activation | ||||||||||||||||||||
| 参考文献： | 1. Syeda R, et al. Chemical activation of the mechanotransduction channel Piezo1. Elife. 2015 May 22;4. 2. Dela Paz NG, et al. Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun. 2018 Feb 26;497(1):220-225. 3. Kuriyama M, et al. Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells. Sci Rep. 2022 Apr 15;12(1):6322. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京