| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85497-5mg |
≥99%(HPLC) | ￥740.00 |
7 | - | - | - | - |
|
S85497-10mg |
≥99%(HPLC) | ￥1080.00 |
3 | - | - | - | - |
|
S85497-25mg |
≥99%(HPLC) | ￥2630.00 |
2 | - | - | - | - |
|
S85497-50mg |
≥99%(HPLC) | ￥4400.00 |
1 | - | - | - | - |
|
S85497-100mg |
≥99%(HPLC) | ￥7100.00 |
2 | - | - | - | - |
|
| 产品描述： | AZM475271 is a potent and selective inhibitor of Src kinase(IC50 : 5 nM) | ||||||||||||||||||||
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| 体外研究： | AZM475271 demonstrated strong dose-dependent inhibition of Src tyrosine kinase activity in the L3.6pl human pancreatic carcinoma cell line. The IC50 concentration of AZM475271 to inhibit the phosphorylation of c-src, lck, and c-yes was 0.01, 0.03, and 0.08 μmol/L, respectively, in comparison with an IC50 of 0.7 μmol/L AZM475271 to inhibit KDR. Maximum reduction of Src kinase activity was observed after incubation for 4 hours with ≥5 μmol/L. | ||||||||||||||||||||
| 体内研究： | Treatment with gemcitabine or AZM475271 alone did not significantly change animal weight. In vivo: Tumors appeared to be palpable at day 14 after tumor cell injection in all animals except mice treated with both AZM475271 and gemcitabine, in which the earliest possible palpation of the tumors was at day 17 after tumor cell injection. | ||||||||||||||||||||
| 参考文献： | 1. Plé PA, et al. Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src. J Med Chem. 2004 Feb 12;47(4):871-87. 2. Yezhelyev MV, et al. Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. Clin Cancer Res. 2004 Dec 1;10(23):8028-36. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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