| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85536-1mg买3赠1 |
97.10% | ￥210.00 |
8 | - | - | - | - |
|
S85536-5mg买3赠1 |
97.10% | ￥408.00 |
6 | - | - | - | - |
|
S85536-10mg买3赠1 |
97.10% | ￥690.00 |
6 | - | - | - | - |
|
S85536-25mg买3赠1 |
97.10% | ￥1610.00 |
6 | - | - | - | - |
|
S85536-50mg买3赠1 |
97.10% | ￥2520.00 |
5 | - | - | - | - |
|
S85536-100mg买3赠1 |
≥97% | ￥3370.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitive Pim-1 kianse inhibitor with an IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s >20000 nM) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | PIM1:50 nM (IC50);Pim | ||||||||||||||||||||
| 体外研究： | TCS PIM-1 1 (compound 1), a substituted pyridone scaffold, binds convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggests that TCS PIM-1 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2. Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors. TCS PIM-1 1 serves both as a starting point for SAR chemical syntheses and was used for co-crystallization with Pim-1 protein | ||||||||||||||||||||
| 参考文献： | 1. Cheney IW, et al. Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1679-83. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京