货号	规格	价格	上海	北京	珠海	重庆	武汉
S85566-1mg买3赠1	≥98%	￥570.00 S85566-1mg ￥570.00 现货（买3赠1）	2 2	-	-	-	-
S85566-5mg买3赠1	≥98%	￥1480.00 S85566-5mg ￥1480.00 3-5天（买3赠1）	0 货期：3-5天	-	-	-	-
S85566-10mg	≥98%	￥2310.00 S85566-10mg ￥2310.00 3-5天	0 货期：3-5天	-	-	-	-
S85566-25mg	≥98%	￥4530.00 S85566-25mg ￥4530.00 3-5天	0 货期：3-5天	-	-	-	-

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产品名称:

nerinetide

规格或纯度:

Moligand™

靶点：

NMDA Receptor;nNOS

体外研究：

Tat-NR2B9c is a PSD-95 inhibitor, with an EC50 of 6.7 nM for PSD-95d2, representing a >100-fold higher affinity for this domain than for PSD-95d1 (EC50, 0.67 μM). Tat-NR2B9c inhibits NMDAR2A, NMDAR2B, and NMDAR2C binding to PSD-95, with IC50s of 0.5 μM, ∼8 μM, and 0.75 μM, respectively. Tat-NR2B9c also blocks the interaction between PSD-95 and nNOS with an IC50 of ∼0.2 μM. Tat-NR2B9c reduces association of PSD-95 with GluN2B by ∼50% in the YAC128 striatum, decreases NMDA-induced p38 activation in YAC128 striatal tissue, but shows no effect on the NMDA-induced JNK activation

体内研究：

Tat-NR2B9c (10 nmol/g, i.v.) reduces infarction volume of male C57BL/6 mice, but has no effect at 3 nM/g

参考文献：

1. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15. 2. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009. 3. Teves LM, et al. Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species. J Cereb Blood Flow Metab. 2016 Mar;36(3):555-61. 4. Jing Fan, et al. N-methyl-D-aspartate Receptor Subunit- And Neuronal-Type Dependence of Excitotoxic Signaling Through Post-Synaptic Density 9. J Neurochem. 2010 Nov;115(4):1045-56.

溶解性：

Soluble in H2O

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.397 ml	1.985 ml	3.97 ml
5 mM	0.079 ml	0.397 ml	0.794 ml
10 mM	0.04 ml	0.199 ml	0.397 ml
50 mM	0.008 ml	0.04 ml	0.079 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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