货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S85583-5mg	≥98%	￥3490.00 S85583-5mg ￥3490.00 3-5天	0 货期：3-5天	-	-	-	-
S85583-10mg	≥98%	￥4990.00 S85583-10mg ￥4990.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Sortin1 is a chemical genetic-hit molecule that causes specific mislocalization of plant and yeast-soluble and membrane vacuolar markers.

体外研究：

Sortin1 was found to redirect the vacuolar destination of plant carboxypeptidase Y and other proteins in Arabidopsis suspension cells and cause these proteins to be secreted. In Arabidopsis seedlings, the application of Sortin1 and -2 led to reversible defects in vacuole biogenesis and root development. Sortin1 treatment of whole Arabidopsis seedlings also resulted in carboxypeptidase Y secretion, indicating that the drug has a similar mode of action in cells and intact plants. Structure-activity relationship studies conducted in Arabidopsis revealed the structural requirements for Sortin1 bioactivity and demonstrated that overlapping Sortin1 substructures can be used to discriminate between vacuolar-flavonoid accumulations and vacuolar-biogenesis defects

参考文献：

1. Zouhar J, et al. Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9497-501. 2. Orr DJ, et al. 1H NMR-based metabolomics methods for chemical genomics experiments. Methods Mol Biol. 2014;1056:225-39. 3. Rosado A, et al. Sortin1-hypersensitive mutants link vacuolar-trafficking defects and flavonoid metabolism in Arabidopsis vegetative tissues. Chem Biol. 2011 Feb 25;18(2):187-97.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.265 ml	11.327 ml	22.654 ml
5 mM	0.453 ml	2.265 ml	4.531 ml
10 mM	0.227 ml	1.133 ml	2.265 ml
50 mM	0.045 ml	0.227 ml	0.453 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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