| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85596-1mg买3赠1 |
98.70% | ￥70.00 |
8 | - | - | - | - |
|
S85596-2mg买3赠1 |
98.70% | ￥120.00 |
8 | - | - | - | - |
|
S85596-5mg买3赠1 |
98.70% | ￥148.00 |
8 | - | - | - | - |
|
S85596-10mg买3赠1 |
98.70% | ￥252.00 |
6 | - | - | - | - |
|
S85596-25mg促销 |
98.70% | ￥500.00 ￥400.00 |
5 | - | - | - | - |
|
S85596-50mg促销 |
98.70% | ￥740.00 ￥592.00 |
5 | - | - | - | - |
|
S85596-100mg促销 |
≥98% | ￥890.00 ￥712.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IRAK | ||||||||||||||||||||
| 细胞实验： | IRAK-1-4 Inhibitor I is dissolved in DMSO and stored, and then diluted with appropriate media before use. NCM460 cells, grown in 24-well plates, are incubated with 50 μM IRAK-1/4 inhibitor for 2 h. After 2 h, the media are changed, and new media with or without LPS (10 ng/mL) added. Treatment is terminated at 6 h, and spent media and cells are collected for IL-8 and other assays | ||||||||||||||||||||
| 参考文献： | 1.Powers JP, et al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-2845. 2.Bhattacharyya S, et al. Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007 Aug;293(2):G429-37. 3.Wu X, Xu M, Liu Y, et al. Dual Pharmacological Inhibition of IRAK1 and IRAK4 Prevents LPS Induced Monocyte Adhesion to Endothelial Cells[J]. bioRxiv. 2021 | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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