| 产品描述： | MIM-1 is an inhibitor of myeloid cell factor 1 (Mcl-1). |
| 靶点： |
Mcl-1;BCL |
| 体外研究： |
MIM-1 selectively targets the BH3 binding groove of Mcl-1, with Bak-dependent apoptotic activity. To estimate the sensitivity of HA and T98G cells to the apoptosis inhibitor MIM-1, the colorimetric MTT assay is used to detect cell viability and to determine the IC50 value. The IC50 value of the HA cell line is almost 5-fold lower (16.10 µM) compared with the IC50 of the T98G cell line (80.20 µM) after MIM-1 inhibitor treatment. |
| 参考文献： |
1. Vidomanova E, et al. Microfluidic profiling of apoptosis-related genes after treatment with BH3-mimetic agents in astrocyte and glioblastoma cell lines. Oncol Rep. 2016 Dec;36(6):3188-3196. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.878 ml |
14.391 ml |
28.783 ml |
| 5 mM |
0.576 ml |
2.878 ml |
5.757 ml |
| 10 mM |
0.288 ml |
1.439 ml |
2.878 ml |
| 50 mM |
0.058 ml |
0.288 ml |
0.576 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
