货号	规格	价格	上海	北京	珠海	重庆	武汉
S85604-1mg买3赠1	≥99%	￥370.00 ￥330.00 S85604-1mg ￥330.00 现货（买3赠1）	8 8	-	-	-	-
S85604-5mg买3赠1	99.10%	￥630.00 ￥560.00 S85604-5mg ￥560.00 现货（买3赠1）	12 >10	-	-	-	-
S85604-10mg买3赠1	99.10%	￥1010.00 ￥900.00 S85604-10mg ￥900.00 现货（买3赠1）	13 >10	-	-	-	-
S85604-25mg买3赠1	99.10%	￥1900.00 ￥1710.00 S85604-25mg ￥1710.00 现货（买3赠1）	9 9	-	-	-	-
S85604-100mg买3赠1	99.10%	￥4440.00 ￥3990.00 S85604-100mg ￥3990.00 现货（买3赠1）	4 4	-	-	-	-

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产品描述：

Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

靶点：

AChE

体外研究：

Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release.

体内研究：

Absorption of Galanthaminone is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.

参考文献：

1. Greenblatt HM, et al. Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution. FEBS Lett. 1999 Dec 17;463(3):321-6. 2. Heinrich M, et al. Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol. 2004 Jun;92(2-3):147-62.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.505 ml	17.523 ml	35.046 ml
5 mM	0.701 ml	3.505 ml	7.009 ml
10 mM	0.35 ml	1.752 ml	3.505 ml
50 mM	0.07 ml	0.35 ml	0.701 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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