货号	规格	价格	上海	北京	珠海	重庆	武汉
S85617-25mg促销	≥99%	￥512.00 ￥400.00 S85617-25mg ￥400.00 现货	6 6	-	1	-	-
S85617-100mg促销	≥99%	￥1600.00 ￥1270.00 S85617-100mg ￥1270.00 现货	10 10	-	-	-	-
S85617-500mg促销	≥99%	￥4490.00 ￥3590.00 S85617-500mg ￥3590.00 现货	1 1	-	-	-	-

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产品描述：

Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM. Tarenflurbil can be used for Alzheimer's disease research.

靶点：

IC50: 75 μM (RXRα);RetinoidReceptor;Autophagy

体内研究：

Effects of the early and late onset of treatment with Tarenflurbil ((R)-Flurbiprofen) are assessed in C57BL6/J mice that develop a non-remitting form of the disease, and in SJL mice that develop a relapsing-remitting (RR)-EAE. Tarenflurbil ((R)-Flurbiprofen) completely prevents the development of clinical EAE scores in C57BL6/J mice when the treatment is started within 3 days after immunization. This regimen is referred to as preventive treatment. The effect is dose-dependent, and the minimum daily dose for complete prevention is 5 mg/kg/day. Effects of Tarenflurbil ((R)-Flurbiprofen) are comparable to those of Fingolimod (FTY720, 0.5 mg/kg/day), which is used as the positive control. Tarenflurbil ((R)-Flurbiprofen) also significantly reduces clinical EAE scores in C57BL6/J mice when treatment is started shortly before onset of clinical manifestations, referred to as semi-therapeutic (10 mg/kg/day) and reduces clinical scores when the treatment is initiated after full development of the disease on day 13 (5 mg/g/day)

参考文献：

1. You X, et al. Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid. J Neurochem. 2009 Oct;111(1):142-9. 2. Wanngren J, et al. Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. J Biol Chem. 2012 Sep 21;287(39):32640-50. 3. Schmitz K, et al. R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO Mol Med. 2014 Sep 30;6(11):1398-422.

溶解性：

Soluble in DMSO

保存条件：

-20℃;充氩

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.094 ml	20.47 ml	40.94 ml
5 mM	0.819 ml	4.094 ml	8.188 ml
10 mM	0.409 ml	2.047 ml	4.094 ml
50 mM	0.082 ml	0.409 ml	0.819 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

(R)-2-Flurbiprofen