货号	规格	价格	上海	北京	珠海	重庆	武汉
S85639-5mg	≥99%	￥830.00 S85639-5mg ￥830.00 3-5天	0 货期：3-5天	-	-	-	-
S85639-10mg	≥99%	￥1430.00 S85639-10mg ￥1430.00 3-5天	0 货期：3-5天	-	-	-	-
S85639-25mg	≥99%	￥3080.00 S85639-25mg ￥3080.00 3-5天	0 货期：3-5天	-	-	-	-
S85639-50mg	≥99%	￥4930.00 S85639-50mg ￥4930.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

SID 3712249 (MiR-544 Inhibitor 1) is a miR-544 biogenesis inhibitor. SID 3712249 binds directly to the precursor miRNA. SID 3712249 blocks production of the mature microRNA and decreases miR-544, HIF-1α, and ATM transcripts. SID 3712249 can be used in the research of cancers, such as breast cancer

靶点：

MiR-544

体外研究：

SID 3712249 (compound 1, 20 nM, 48 h) disrupts miR-544-mediated inhibition of BMI1 based on significant increases in the RFP/BFP ratio. SID 3712249 (20 nM, 48 h) inhibits precursor but not mature miR-544 binding to BMI1 or mTOR3’-UTR. SID 3712249 (20 nM, 48 h) results in accumulation of pre-miR-544 and a decrease in miR-544 levels in MCF10A cells. SID 3712249 (20 nM, 5 days) induces apoptosis in MDA-MB-231 and MCF- 7 cells and has no effect on cell survival in normoxic conditions. Apoptosis Analysis Cell Line: MDA-MB-231, MCF-7 cells Concentration: 20 nM Incubation Time: 5 days Result: Induced apoptosis and has no effect on cell survival in normoxic conditions (flow cytometric analysis of Annexin V and PI stainning).

体内研究：

SID 3712249 (compound 1, 100 μL of 40 μM, intraperitoneal injection) inhibited tumor growth in MDA-MB-231-GFP-luc tumor model. SID 3712249 (20 nM, pre-treated GFP-labeled MDA-MB-231 cells, intraperitoneal injection) inhibited tumor growth in MDA-MB-231-GFP-luc tumor model. Animal Model: MDA-MB-231-GFP-luc tumor model Dosage: 100 μL of 40 μM Administration: Intraperitoneal injection Result: Inhibited tumor growth (evidenced by live animal bioluminescent imaging) with no overt side effects.Decreased levels of miR-544, ATM, and HIF-1α and increased levels of mTOR (resected tumor samples).

参考文献：

1. Christopher L Haga, et al. Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling. ACS Chem Biol. 2015 Oct 16;10(10):2267-76.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.092 ml	15.461 ml	30.922 ml
5 mM	0.618 ml	3.092 ml	6.184 ml
10 mM	0.309 ml	1.546 ml	3.092 ml
50 mM	0.062 ml	0.309 ml	0.618 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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