| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85675-2mg买3赠1 |
98.00% | ￥110.00 |
5 | - | - | - | - |
|
S85675-5mg买3赠1 |
98.00% | ￥160.00 |
6 | - | - | - | - |
|
S85675-10mg买3赠1 |
98.00% | ￥270.00 |
6 | - | - | - | - |
|
S85675-25mg促销 |
98.00% | ￥550.00 ￥440.00 |
5 | - | - | - | - |
|
S85675-50mg促销 |
98.00% | ￥710.00 ￥568.00 |
5 | - | - | - | - |
|
S85675-100mg促销 |
≥98% | ￥1380.00 ￥1100.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | NKL 22 (compound 4b) is a potent and selective inhibitor of histone deacetylases (HDAC), with an IC50 of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 exhibits selectivity over HDAC2/4/5/7/8 (IC50≥1.59 μM). NKL 22 ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | HDAC1：0.199 μM (IC50)；HDAC2：1.59 μM (IC50)；HDAC3：0.069 μM (IC50)；HDAC8：5 μM (IC50);HDAC | ||||||||||||||||||||
| 参考文献： | 1. Jia H, et, al. Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease. Neurobiol Dis. 2012 May;46(2):351-61. 2. D Herman et al. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol, 2006 Oct, 2(10):551-8. 3. Thomas EA, et, al. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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