货号	规格	价格	上海	北京	珠海	重庆	武汉
S85724-5mg买3赠1	98.20%	￥70.00 S85724-5mg ￥70.00 现货（买3赠1）	6 6	-	-	-	-
S85724-10mg	98.20%	￥100.00 S85724-10mg ￥100.00 现货	7 7	-	-	-	-
S85724-50mg	98.20%	￥350.00 S85724-50mg ￥350.00 现货	5 5	-	-	-	-
S85724-100mg	98.20%	￥660.00 S85724-100mg ￥660.00 现货	5 5	-	-	-	-

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产品描述：

TOFA is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).

靶点：

Acetyl-CoA Carboxylase;Acetyl-CoACarboxylase

体内研究：

The tumor growth rate is signifi?cantly inhibited by TOFA compared with the DMSO treated control mice (1649±356.3 vs. 5128±390.4 mm3. No toxicity is observed in the heart, liver, spleen, lung, kidney and intestinal tissues. TOFA inhibits COC1/DDP cell growth in ovarian tumor mouse xenografts. By inhibiting ACC, TOFA may be a promising small molecule agent for ovarian cancer therapy.

细胞实验：

NCI-H460, human lung cancer cells, and HCT-8 and HCT-15 cells (5,000/well) are seeded in 96-well plates overnight and then exposed to TOFA at indicated concentrations (0, 1, 5, 10, 20, 50 μg/mL) for 72 hours. Viable cells are detected using MTT assay

参考文献：

1.Li S, et al. TOFA suppresses ovarian cancer cell growth in vitro and in vivo. Mol Med Rep. 2013 Aug;8(2):373-8. 2.Wang C, et al. Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis. Biochem Biophys Res Commun. 2009 Jul 31;385(3):302-6. 3.Guseva NV, et al. TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status. Cancer Biol Ther. 2011 Jul 1;12(1):80-5.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.082 ml	15.411 ml	30.821 ml
5 mM	0.616 ml	3.082 ml	6.164 ml
10 mM	0.308 ml	1.541 ml	3.082 ml
50 mM	0.062 ml	0.308 ml	0.616 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

5-(TETRADECYLOXY)-2-FUROIC ACID