| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85753-5mg |
≥98% | ￥280.00 |
货期：3-5天 | - | - | - | - |
|
S85753-10mg |
≥98% | ￥450.00 |
货期：3-5天 | - | - | - | - |
|
S85753-25mg |
≥98% | ￥900.00 |
货期：3-5天 | - | - | - | - |
|
S85753-50mg |
≥98% | ￥1460.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | PSB-12062 is a potent and selective P2X4 antagonist with an IC50 of 1.38 μM for human P2X4. | ||||||||||||||||||||
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| 靶点： | IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4);P2XReceptor | ||||||||||||||||||||
| 体外研究： | PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM) | ||||||||||||||||||||
| 参考文献： | 1. Hernandez-Olmos V, et al. N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists. J Med Chem. 2012 Nov 26;55(22):9576-88. 2. Stokes L, et al. P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.Front Pharmacol. 2017 May 23;8:291. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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