| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85793-5mg买3赠1 |
99.80% | ￥135.00 |
6 | - | - | - | - |
|
S85793-10mg买3赠1 |
99.80% | ￥239.00 |
8 | - | - | - | - |
|
S85793-25mg促销 |
99.80% | ￥390.00 ￥312.00 |
6 | - | - | - | - |
|
S85793-50mg促销 |
99.80% | ￥690.00 ￥552.00 |
5 | - | - | - | - |
|
S85793-100mg促销 |
≥98% | ￥1180.00 ￥944.00 |
货期：2-3天 | - | - | - | - |
|
S85793-200mg促销 |
≥98% | ￥1770.00 ￥1410.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | URB602 is a selective monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL with IC50 of 28±4 μM through a noncompetitive mechanism. | ||||||||||||||||||||
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| 靶点： | IC50: 28±4 μM (rat brain MGL);Lipase;Antibacterial | ||||||||||||||||||||
| 体内研究： | URB602 at doses of 20 and 40 mg/kg tends to reduce upper GI transit and slow colonic propulsion. When taken together as whole gut transit, URB602 dose dependently inhibits transit (P<0.05) compared with the vehicle control group. The inhibitory action of 40 mg/kg URB602 on whole gut transit is absent in these mice, indicating CB1 receptor involvement in the inhibitory action. URB602 decreases the AUC of pain behaviour during the early phase of the formalin test with an ED50 of 0.06±0.028 μg for JZL184 and 120±51.3 μg for URB602 in adult male Sprague-Dawley rats. Both MGL inhibitors also suppresses pain behaviour during the late phase of formalin pain, with an ED50 of 0.03±0.011 μg for JZL184 and 66±23.9 μg for URB602 | ||||||||||||||||||||
| 参考文献： | 1. Hohmann AG, et al. An endocannabinoid mechanism for stress-induced analgesia. Nature. 2005 Jun 23;435(7045):1108-12. 2. King AR, et al. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. Chem Biol. 2007 Dec;14(12):1357-65. 3. Duncan M, et al. Distribution and function of monoacylglycerol lipase in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1255-65. 4. Guindon J, et al. Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. Br J Pharmacol. 2011 Aug;163(7):1464-78. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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