货号	规格	价格	上海	北京	珠海	重庆	武汉
S85800-1mg买3赠1	99.90%	￥70.00 S85800-1mg ￥70.00 现货（买3赠1）	6 6	-	-	-	-
S85800-2mg买3赠1	99.90%	￥100.00 S85800-2mg ￥100.00 现货（买3赠1）	7 7	-	-	-	-
S85800-5mg买3赠1	99.90%	￥180.00 S85800-5mg ￥180.00 现货（买3赠1）	6 6	-	-	-	-
S85800-10mg买3赠1	99.90%	￥300.00 S85800-10mg ￥300.00 现货（买3赠1）	6 6	-	-	-	-
S85800-25mg促销	99.90%	￥420.00 ￥336.00 S85800-25mg ￥336.00 现货	5 5	-	-	-	-
S85800-50mg促销	99.90%	￥620.00 ￥496.00 S85800-50mg ￥496.00 现货	5 5	-	-	-	-

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产品描述：

AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research

靶点：

CCR4;CCR

体外研究：

AZD2098 potently inhibits chemokine-induced cellular responses, with pIC50 of 7.5 and 6.3 against CCL22-induced Ca2+ influx in hCCR4-expressing CHO cells and CCL17- or CCL22-induced chemotaxis of primary human Th2 cells respectively

体内研究：

AZD2098 (73.5-5.0 μg/kg; p.o.; BID; twice a day; 1 hour before and every 12 hours after antigen challenge) exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats, and the changes are first visible at a dose of 0.22 µmol/kg and maximal at 7.5 µmol/kg. Animal Model: Brown-Norway rats Dosage: 73.5 µg/kg, 250.6 µg/kg, 735.2 µg/kg, 1.0 mg/kg, 2.5 mg/kg, 5.0 mg/kg Administration: Oral administration; twice a day; 1 hour before and every 12 hours after antigen challenge Result: Exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats.

参考文献：

1. Kindon N, et al. Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986. 2. Asher Mullard. Cancer charity sees success re-prioritizing industry's shelved compounds. Nat Rev Drug Discov. 2014 May;13(5):319-21.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.992 ml	14.962 ml	29.924 ml
5 mM	0.598 ml	2.992 ml	5.985 ml
10 mM	0.299 ml	1.496 ml	2.992 ml
50 mM	0.06 ml	0.299 ml	0.598 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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