| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85801-1mg促销 |
≥98% | ￥399.00 ￥310.00 |
10 | - | - | - | - |
|
S85801-5mg促销 |
≥98% | ￥1390.00 ￥1110.00 |
10 | - | - | - | - |
|
S85801-10mg促销 |
≥98% | ￥2230.00 ￥1780.00 |
10 | - | - | - | - |
|
S85801-25mg促销 |
≥98% | ￥4460.00 ￥3570.00 |
10 | - | - | - | - |
|
S85801-50mg促销 |
≥98% | ￥7140.00 ￥5710.00 |
8 | - | - | - | - |
|
S85801-100mg促销 |
≥98% | ￥10000.00 ￥7990.00 |
2 | - | - | - | - |
|
| 产品描述： | BHPI is a potent inhibitor of nuclear estrogen–ERα-regulated gene expression; elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), and persistent inhibition of protein synthesis. IC50 value: Target: ERα inhibitor BHPI is effective because it elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), and persistent inhibition of protein synthesis. BHPI distorts a newly described action of estrogen-ERα: mild and transient UPR activation. In contrast, BHPI elicits massive and sustained UPR activation, converting the UPR from protective to toxic. In ERα(+) cancer cells, BHPI rapidly hyperactivates plasma membrane PLCγ, generating inositol 1,4,5-triphosphate (IP3), which opens EnR IP3R calcium channels, rapidly depleting EnR Ca(2+) stores. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Estrogen Receptor/ERR | ||||||||||||||||||||
| 体内研究： | BHPI (10-15 mg/kg；腹腔注射；每日一次，10 天或每隔一天一次，直至实验结束) 在使用 MCF-7 肿瘤的异种移植小鼠模型中抑制肿瘤生长，导致中 48/52 肿瘤迅速消退。 | ||||||||||||||||||||
| 参考文献： | 1. Andruska ND, et al. Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4737-42. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京