| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85835-1mg买3赠1 |
99.60% | ￥120.00 |
>10 | - | - | - | - |
|
S85835-2mg买3赠1 |
99.60% | ￥204.00 |
>10 | - | - | - | - |
|
S85835-5mg买3赠1 |
99.60% | ￥255.00 |
>10 | - | - | - | - |
|
S85835-10mg买3赠1 |
99.60% | ￥380.00 |
>10 | - | - | - | - |
|
S85835-25mg买3赠1 |
99.60% | ￥714.00 |
>10 | - | - | - | - |
|
S85835-50mg买3赠1 |
99.60% | ￥1100.00 |
>10 | 2 | - | - | - |
|
S85835-100mg买3赠1 |
≥99% | ￥1780.00 |
>10 | - | - | - | - |
|
| 产品描述： | Fexaramine is a potent and selective FXR agonist with an EC50 of 25 nM. Fexaramine has no activity against hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, and hVDR receptors | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | FXR;Autophagy | ||||||||||||||||||||
| 体内研究： | Fexaramine treatment of DIO mice produces a striking metabolic profile that includes reduced weight gain, decreased inflammation, browning of WAT and increased insulin sensitization | ||||||||||||||||||||
| 参考文献： | 1. Lam IP, et al. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP). Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G90-7. 2. Michael Downes, et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr;11(4):1079-92. 3. Fang S, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb;21(2):159-65. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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