| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85836-1mg买3赠1 |
99.20% | ￥204.00 |
9 | - | - | - | - |
|
S85836-2mg买3赠1 |
99.20% | ￥340.00 |
9 | - | - | - | - |
|
S85836-5mg买3赠1 |
99.20% | ￥510.00 |
6 | - | - | - | - |
|
S85836-10mg买3赠1 |
99.20% | ￥850.00 |
6 | - | - | - | - |
|
S85836-25mg促销 |
99.20% | ￥1490.00 ￥1190.00 |
6 | - | - | - | - |
|
S85836-50mg促销 |
99.20% | ￥2440.00 ￥1950.00 |
5 | - | - | - | - |
|
S85836-100mg促销 |
99.20% | ￥3500.00 ￥2800.00 |
4 | - | - | - | - |
|
| 产品描述： | R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk) kinase. R112 inhibits Syk kinase activity with an IC50 value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis | ||||||||||||||||||||
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| 靶点： | IC50: 226 nM (Syk kinase);Syk | ||||||||||||||||||||
| 体外研究： | R112 (0.001-10 μM; 1 h) dose-dependently inhibits anti-IgE-mediated tryptase release and histamine release with EC50s of 0.353 and 0.28 μM, inhibits histamine release by basophils stimulated with an EC50 value of 0.49 μM, inhibits secretion of LTC4, TNF-α, GM-CSF and IL-8 with EC50s of 0.115, 2.01, 1.58 and 1.75 μM, respectively. R112 (0-10 μM; 40 min) inhibits Syk target LAT (Y191) phosphorylation. Western Blot Analysis Cell Line: Human mast cells Concentration: 0.4, 2 and 10 μM Incubation Time: 40 min Result: Inhibited phosphorylation of the Syk target LAT (Y191) and also inhibited phosphorylation of Syk downstream events. | ||||||||||||||||||||
| 参考文献： | 1. Rossi AB, et al. Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J Allergy Clin Immunol. 2006 Sep;118(3):749-755. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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