货号	规格	价格	上海	北京	珠海	重庆	武汉
S85844-1mg买3赠1	98.10%	￥544.00 S85844-1mg ￥544.00 现货（买3赠1）	8 8	-	-	-	-
S85844-2mg买3赠1	98.10%	￥816.00 S85844-2mg ￥816.00 现货（买3赠1）	9 9	-	-	-	-
S85844-5mg买3赠1	98.10%	￥1140.00 S85844-5mg ￥1140.00 现货（买3赠1）	7 7	-	-	-	-
S85844-10mg买3赠1	98.10%	￥2040.00 S85844-10mg ￥2040.00 现货（买3赠1）	7 7	-	-	-	-
S85844-25mg买3赠1	98.10%	￥3690.00 S85844-25mg ￥3690.00 现货（买3赠1）	4 4	-	-	-	-
S85844-50mg	≥98%	￥6700.00 S85844-50mg ￥6700.00 2-3天	0 货期：2-3天	-	-	-	-
S85844-100mg	≥98%	￥9100.00 S85844-100mg ￥9100.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.

靶点：

TNF

体内研究：

Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. Body weight loss and colon tissue edematous inflammation are recovered significantly. The oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner.

动物实验：

Hispidol is prepapred in corn oil.Rat: To study the effect of the drugs, hispidol (10 or 30 mg/Kg/day in corn oil) is administered orally once in a day, until 5 days after TNBS administration. The doses of 10 or 30 mg/kg are selected based on previous studies. The concentration of the compound inhibiting 70% and 90% (μM) cell-to-cell adhesion is selected and regarded as the in vivo test dose (mg/kg). Sulfasalazine (300 mg/Kg/day) is administered in corn oil as a positive control. On the 6th day, the rats are sacrificed and the severity of colitis and macroscopic ulceration are evaluated by two independent investigators who are blinded to the experiments. The colon tissues (5-7 cm proximal to rectum) are cut and used to measure the amount of myeloperoxidase and for the histological examinations

参考文献：

1.Kadayat TM, et al. Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. Eur J Med Chem. 2017 Sep 8;137:575-597.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.693 ml	18.467 ml	36.933 ml
5 mM	0.739 ml	3.693 ml	7.387 ml
10 mM	0.369 ml	1.847 ml	3.693 ml
50 mM	0.074 ml	0.369 ml	0.739 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

6,4''-DIHYDROXYAURONE