货号	规格	价格	上海	北京	珠海	重庆	武汉
S85861-100mg买3赠1	99.03%	￥120.00 S85861-100mg ￥120.00 现货（买3赠1）	1 1	-	-	-	-
S85861-500mg	99.03%	￥360.00 S85861-500mg ￥360.00 现货	2 0 2	-	-	-	-
S85861-1g	99.03%	￥615.00 S85861-1g ￥615.00 现货	2 2	-	-	-	-

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产品描述：

Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.

靶点：

Ki: 4 nM (NET), 61 nM (SERT), 78720 nM (DAT);DopamineReceptor;5-HTReceptor;SerotoninTransporter;AdrenergicReceptor

体内研究：

Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3H-nisoxetine to the NET in preparations of cerebral cortex (F(3,16)=4.33, p<0.05) and hippocampus (F(3,16)=4.34, p<0.05). This NET down regulation is observed 2 days after discontinuation of chronic Desipramine hydrochloride treatment, a time when plasma and brain concentrations of Desipramine hydrochloride and desmethyldesipramine are undetectable (ie below the 25 ng detection limit of the assay)

参考文献：

1. Torres GE, et al. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci. 2003 Jan;4(1):13-25. 2. Zhao Z, et al. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology. 2008 Dec;33(13):3190-200.

溶解性：

Soluble in DMSO、H2O

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.302 ml	16.51 ml	33.02 ml
5 mM	0.66 ml	3.302 ml	6.604 ml
10 mM	0.33 ml	1.651 ml	3.302 ml
50 mM	0.066 ml	0.33 ml	0.66 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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Desipramine Hydrochloride