源叶(MedMol)
S85957
一键复制产品信息
609799-22-6
C15H19NO2
245.32
(1R-TRANS)-N-[[2-(2,3-二氢-4-苯并呋喃基)环丙基]甲基]丙酰胺;他司美琼杂质;他司美琼杂质A;tasimelteon;(1R-trans)-N-[[2-(2,3-Dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide;BMS 214778;MA 1;VEC 162;TasiMelteon/BMS214778;Tasimelteon
他司美琼 97%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85957-5mg |
97% | ￥302.00 |
3 | 3 | 2 | - | - |
|
S85957-10mg促销 |
97% | ￥648.00 ￥582.00 |
货期：3-5天 | 2 | 2 | 3 | - |
|
S85957-25mg促销 |
97% | ￥1060.00 ￥959.00 |
2 | 1 | 2 | - | - |
|
S85957-100mg促销 |
97% | ￥3230.00 ￥2910.00 |
货期：3-5天 | 1 | 1 | - | - |
|
| 产品描述： | Tasimelteon (BMS 214778, VEC 162) is a selective dual melatonin receptor (MT1/MT2) agonist with 2.1-4.4 times greater affinity for the MT2 receptor believed to mediate circadian rhythm phase-shifting (Ki = 0.0692 nM and Ki = 0.17 nM in NIH-3T3 and CHOeK1 cells, respectively), than for the MT1 receptor (Ki = 0.304 nM and Ki = 0.35 nM, respectively). | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | MT2 receptor:9.8(pKi);MT1 receptor:9.45(pKi);MelatoninReceptor;MTReceptor | ||||||||||||||||||||
| 体内研究： | In rats and monkeys, the half-life of tasimelteon was approximately 2 h which is longer than the half-life of melatonin. Tasimelteon has a mean absolute bioavailability of approximately 38.3%. The higher oral-to-IV exposure ratios and decrease in the metabolite-to-parent ratios after IV administration for tasimelteon's metabolites indicate that although tasimelteon is subject to first-pass metabolism, a substantial fraction of its metabolism occurs post- rather than presystemically. Both oral and IV tasimelteon were well tolerated | ||||||||||||||||||||
| 参考文献： | 1. Lankford DA. Expert Opin Investig Drugs. 2011, 20(7):987-93. 2. Torres R1, et al. Am J Ther. 2015, 22(5):355-60. 3. Rosarelis Torres, et al. J Clin Pharmacol. 2015, 55(5): 525–533. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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