货号	规格	价格	上海	北京	珠海	重庆	武汉
S85977-25mg买3赠1	99.91%	￥60.00 S85977-25mg ￥60.00 现货（买3赠1）	4 4	-	-	-	-
S85977-100mg买3赠1	99.91%	￥130.00 S85977-100mg ￥130.00 现货（买3赠1）	11 >10	-	-	-	-
S85977-500mg	99.91%	￥260.00 S85977-500mg ￥260.00 现货	7 0 7	-	-	-	-

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产品描述：

DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.

靶点：

Calcium Channel;CalciumChannel

体外研究：

DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor.

参考文献：

1. Kang JJ, et al. Effects of bipyridylium compounds on calcium release from triadic vesicles isolated from rabbit skeletal muscle. Br J Pharmacol. 1994 Aug;112(4):1216-22.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.944 ml	9.72 ml	19.441 ml
5 mM	0.389 ml	1.944 ml	3.888 ml
10 mM	0.194 ml	0.972 ml	1.944 ml
50 mM	0.039 ml	0.194 ml	0.389 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

DHBP dibromide ( Diheptylviologen dibromide)

1,1'-Diheptyl-[4,4'-bipyridine]-1,1'-diium bromide

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)