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CCG-63802,G蛋白信号传导4(RGS4)蛋白调节剂的抑制剂

    
98%

CCG-63802

源叶(MedMol)
S85987 一键复制产品信息
620112-78-9
C26H18N4O2S
450.52
CCG-63802
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S85987-5mg促销
98%

¥500.00 ¥450.00

10 - - - -
S85987-10mg促销
98%

¥746.00 ¥670.00

7 - - - -
S85987-25mg促销
98%

¥1850.00 ¥1660.00

8 - - - -
S85987-50mg促销
98%

¥3200.00 ¥2880.00

1 - - - -
S85987-100mg促销
98%

¥5200.00 ¥4680.00

1 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: CCG-63802 is a selective, reversible and allosteric RGS4 inhibitor. CCG-63802 specifically binds to RGS4 and blocks the RGS4-Gαo interaction, with an IC50 value of 1.9 μM
靶点: RGS4:1.9 μM (IC50);GTPase
体内研究: CCG-63802 (0.05 mg/kg; intratracheal administration; once per week; 90 days) reduces RGS4 protein expression, leading to partially abrogate the attenuating effect of PGZ on airway inflammation, hyperresponsiveness (AHR), and remodelin Animal Model: Forty female BALB/c mice aged 6-8 week old Dosage: 0.05 mg/kg Administration: Intratracheal administration; once per week; 90 days Result: CCG 63802 treatment in OVA +PGZ + CCG group significantly reduced RGS4 protein expression compared to OVA + PGZ group (P < 0.05)
参考文献: 1. Levi L Blazer, et al. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol Pharmacol. 2010 Sep;78(3):524-33. 2. Marina Dobrivojević, et al. Interaction between bradykinin and natriuretic peptides via RGS protein activation in HEK-293 cells. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1260-8. 3. Xia Meng, et al. PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model. Inflammation. 2018 Dec;41(6):2079-2089.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.22 ml 11.098 ml 22.197 ml
5 mM 0.444 ml 2.22 ml 4.439 ml
10 mM 0.222 ml 1.11 ml 2.22 ml
50 mM 0.044 ml 0.222 ml 0.444 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

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