| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85987-5mg促销 |
98% | ￥500.00 ￥450.00 |
10 | - | - | - | - |
|
S85987-10mg促销 |
98% | ￥746.00 ￥670.00 |
7 | - | - | - | - |
|
S85987-25mg促销 |
98% | ￥1850.00 ￥1660.00 |
8 | - | - | - | - |
|
S85987-50mg促销 |
98% | ￥3200.00 ￥2880.00 |
1 | - | - | - | - |
|
S85987-100mg促销 |
98% | ￥5200.00 ￥4680.00 |
1 | - | - | - | - |
|
| 产品描述： | CCG-63802 is a selective, reversible and allosteric RGS4 inhibitor. CCG-63802 specifically binds to RGS4 and blocks the RGS4-Gαo interaction, with an IC50 value of 1.9 μM | ||||||||||||||||||||
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| 靶点： | RGS4:1.9 μM (IC50);GTPase | ||||||||||||||||||||
| 体内研究： | CCG-63802 (0.05 mg/kg; intratracheal administration; once per week; 90 days) reduces RGS4 protein expression, leading to partially abrogate the attenuating effect of PGZ on airway inflammation, hyperresponsiveness (AHR), and remodelin Animal Model: Forty female BALB/c mice aged 6-8 week old Dosage: 0.05 mg/kg Administration: Intratracheal administration; once per week; 90 days Result: CCG 63802 treatment in OVA +PGZ + CCG group significantly reduced RGS4 protein expression compared to OVA + PGZ group (P < 0.05) | ||||||||||||||||||||
| 参考文献： | 1. Levi L Blazer, et al. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol Pharmacol. 2010 Sep;78(3):524-33. 2. Marina Dobrivojević, et al. Interaction between bradykinin and natriuretic peptides via RGS protein activation in HEK-293 cells. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1260-8. 3. Xia Meng, et al. PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model. Inflammation. 2018 Dec;41(6):2079-2089. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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