货号	规格	价格	上海	北京	珠海	重庆	武汉
S85989-5mg促销	99.80%	￥1440.00 ￥1150.00 S85989-5mg ￥1150.00 现货	5 5	-	-	-	-
S85989-10mg促销	99.80%	￥2200.00 ￥1760.00 S85989-10mg ￥1760.00 现货	5 5	-	-	-	-
S85989-25mg促销	99.80%	￥3530.00 ￥2820.00 S85989-25mg ￥2820.00 现货	5 5	-	-	-	-
S85989-100mg促销	≥98%	￥6900.00 ￥5520.00 S85989-100mg ￥5520.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings. Target: HIF2α Limited trypsin proteolysis reveals that both apo and THS-044-bound protein are efficiently cut at R330 in the extended HI loop. In the THS-044 bound state, there appears no additional proteolysis at the remaining candidate trypsin sites. In contrast, these THS-044-protected sites are protease accessible in the unliganded protein, leading its complete degradation. In parallel, NMR-based deuterium exchange measurements revealed a dramatic stabilization of the THS-044-bound protein β-sheet, with some sites experiencing 100-fold enhanced protection factors relative to the ligand-free protein.

靶点：

HIF/HIF Prolyl-Hydroxylase;HIF

参考文献：

1: Motto I, Bordogna A, Soshilov AA, Denison MS, Bonati L. New aryl hydrocarbon receptor homology model targeted to improve docking reliability. J Chem Inf Model. 2011;51(11):2868-2881. doi:10.1021/ci2001617
2: Scheuermann TH, Tomchick DR, Machius M, Guo Y, Bruick RK, Gardner KH. Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc Natl Acad Sci U S A. 2009;106(2):450-455. doi:10.1073/pnas.0808092106

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.434 ml	17.169 ml	34.338 ml
5 mM	0.687 ml	3.434 ml	6.868 ml
10 mM	0.343 ml	1.717 ml	3.434 ml
50 mM	0.069 ml	0.343 ml	0.687 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

THS-044

N-(2-nitro-4-(trifluoromethyl)phenyl)morpholin-4-amine

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)