货号	规格	价格	上海	北京	珠海	重庆	武汉
S86019-5mg	≥98%	￥380.00 S86019-5mg ￥380.00 3-5天	0 货期：3-5天	-	-	-	-
S86019-10mg	≥98%	￥610.00 S86019-10mg ￥610.00 3-5天	0 货期：3-5天	-	-	-	-
S86019-25mg	≥98%	￥1290.00 S86019-25mg ￥1290.00 3-5天	0 货期：3-5天	-	-	-	-
S86019-100mg	≥98%	￥3000.00 S86019-100mg ￥3000.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

SU14813 is a multi-targeted receptor tyrosine kinases inhibitor with IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT.

靶点：

VEGFR1:2 nM (IC50);VEGFR2:50 nM (IC50);PDGFRβ:4 nM (IC50);KIT:15 nM (IC50);VEGFR;PDGFR;c-Kit

体外研究：

SU14813 inhibits ligand-dependent and ligand-independent proliferation, migration, and survival of endothelial cells and/or tumor cells expressing these targets. SU14813 inhibits cellular ligand-dependent phosphorylation of VEGFR-2 (transfected NIH 3T3 cells), PDGFR-β (transfected NIH 3T3 cells), KIT (Mo7e cells), and FLT3-internal tandem duplication (FLT3-ITD; MV4;11 cells) as well as FMS/CSF1R (transfected NIH 3T3 cells). SU14813 inhibits VEGFR-2, PDGFR-β, and KIT phosphorylation in porcine aorta endothelial cells overexpressing these targets, with cellular IC50 values of 5.2, 9.9, and 11.2 nM, respectively. SU14813 inhibits the growth of U-118MG with an IC50 of 50 to 100 nM

体内研究：

SU14813 inhibits VEGFR-2, PDGFR-β, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent fashion. The plasma concentration required for in vivo target inhibition is estimated to be 100 to 200 ng/mL. Used as monotherapy, SU14813 exhibits broad and potent antitumor activity resulting in regression, growth arrest, or substantially reduces growth of various established xenografts derived from human or rat tumor cell lines. Treatment in combination with docetaxel significantly enhances both the inhibition of primary tumor growth and the survival of the tumor-bearing mice compared with administration of either agent alone

参考文献：

1. Patyna S, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther. 2006 Jul;5(7):1774-82.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.26 ml	11.3 ml	22.599 ml
5 mM	0.452 ml	2.26 ml	4.52 ml
10 mM	0.226 ml	1.13 ml	2.26 ml
50 mM	0.045 ml	0.226 ml	0.452 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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