货号	规格	价格	上海	北京	珠海	重庆	武汉
S86109-5mg	≥98%	￥1050.00 S86109-5mg ￥1050.00 3-5天	0 货期：3-5天	-	-	-	-
S86109-10mg	≥98%	￥1790.00 S86109-10mg ￥1790.00 3-5天	0 货期：3-5天	-	-	-	-
S86109-25mg	≥98%	￥3200.00 S86109-25mg ￥3200.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM

靶点：

Ki: 90 pM (MTAP)

体外研究：

Treatment of cultured cells with MT-DADMe-ImmA and MTA inhibit MTAP, increase cellular MTA concentrations, decrease polyamines, and induce apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines. The same treatment does not induce apoptosis in normal human fibroblast cell lines (CRL2522 and GM02037) or in MCF7, a breast cancer cell line with an MTAP gene deletion. MT-DADMe-ImmA alone does not induce apoptosis in any cell line, implicating MTA as the active agent

体内研究：

The t1/2 for onset of inhibition is 50 min with complete inhibition by 250 min. MTAP activity slowly returns, giving a biological half-life for the action of oral MT-DADMe-ImmA of 6.3 days. The time-dependent growth of FaDu tumors in immunodeficient mice is suppressed by oral or intraperitoneal treatment with MT-DADMe-ImmA

参考文献：

1. Evans GB, et al. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem. 2005 Jul 14;48(14):4679-89. 2. Basu I, et al. A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. J Biol Chem. 2007 Jul 20;282(29):21477-86.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.408 ml	17.042 ml	34.085 ml
5 mM	0.682 ml	3.408 ml	6.817 ml
10 mM	0.341 ml	1.704 ml	3.408 ml
50 mM	0.068 ml	0.341 ml	0.682 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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